Introduction
Introduction, correct patient, consent, wash hands (WINDEC), any pain
Adequate exposure
End of the bed inspection
CN I-XII
CN I - Any change to sense of smell (vanilla essence is rarely used)
CN II (Eyes)
Offer Fundoscopy (shouldn't have to do it)
Visual acuity- ask about glassses, offer- Snellen chart + one eye at a time; with glasses on ask to tell the time of the clock (colour- Ishihara plates)
Visual fields - both eyes, left & right eye - central & peripheral
Pupillary response to light- direct & indirect, RAPD- pupil dilates with light (CN II, III)
CN III, IV, VI- eye movements
Draw H,
Finger-palm: vertical/ horizontal
Accommodation response (look into distance then finger close)
CN V
Fine touch V1, V2, V3; (near midline to avoid cervical nerves)
Jaw open- don't let me close mouth, masseter muscle
Jaw Reflex- abnormal to close, normal: no response
CN VII
Eye brows to ceiling, close eyes (attempt to open)
Puff cheeks, show teeth, purse lips (don't let me open mouth)
CN VIII
Hearing b/l- whisper number + rub fingers together & ask to repeat
CN IX, X
Open mouth, say arh- palatal movements; uvula
Cough, uvula (X)
Swallow (IX, XI, XII)
Speech (V, VII, X, XII)
CN XI
Neck rotation + resistance
Shrug shoulders + resistance
CN XII
Tongue in mouth + movements
Functions not assessed:
Corneal reflex (V, VII)
Gag reflex (IX, X)
Sensation to pain and temperature
Conclusion
Thank patient, help to re-dress, wash hands.
Inspection
Muscle wasting, fasciculations - LMN
Eye patch, walking aids, weakness in limbs, immune modulation
Absent Smell- Post Viral (Covid), Parkinson's, Kalman's,
Visual Acuity- reduced
Pupil
Enlarged (mydriasis): CN III Palsy
Small (miosis): Horner's Syndrome
RAPD- optic neuritis, glaucoma, macular degeneration, infection e.g. herpes
Eye movements:
Palsy- Cranial Nerve III, Trochlear, Abducens
INO (Internuclear ophthalmoplegia)- Right lesion: normal movements looking to right, looking to left- right eye can't adduct & left eye abducts with nystagmus
CN V Palsy- facial numbness, jaw jerk (UMN- MND), masseter weakness
CN VII - Forehead sparing (UMN), Forehead included (LMN)- Bell's Palsy, Ramsay Hunt, Parotid tumour
CN VIII
Hearing loss- Alport's, presbycusis
Vestibular ataxia
Speech- UMN lesion (brain)- right hemisphere, likely Stroke
Expressive (Broca)
Fluent (Wernicke's)
Staccato (Cerebellar Ataxia)
Parkinson's- hypophonia (quiet voice), monotone speech
Swallow, Cough: sign of respiratory dysfunction in MND, GBS
CN IX- uvulA deviates AWAY from lesion
CN XII- neck & shoulder weakness
CN XII- Tongue deviates TOWARDS lesion
Tongue: bag of worms fasciculations- MND
Tongue tremor: Parkinson's
Mononeuropathies
Oculomotor Nerve Palsy (Cranial Nerve III)- unilateral affected eye, fixed in down and out; ptosis +- mihydrosis
Trochlear Cranial Nerve IV Palsy- inability to move affected eye inferior at ADDuction, head tilted
Abducens Cranial Nerve VI Palsy- inability to ABDuct affected eye
Bell's palsy: unilateral paralysis of all 3 segments of face
Localising Signs
UMN - jaw jerk, forehead sparing
LMN - facial weakness including forehead, muscle wasting, fasiculations
Systemic Conditions
Complex Ophthalmoplegia
Multiple eye signs not fitting into one cranial nerve:
Myotonic Dystrophy
Ophthalmoplegic Migraine- painful mononeuropathy that self resolves
Introduction
Headline
Details
Differentials
Complications
Complete assessment
Investigations
Management
Examples
Confident of MND
I've examined Mr Jones' cranial nerves. My findings are consistent with motor neuron disease. I identified muscle wasting and fasiculations bilaterally and power was reduced throughout the face. Of note there were tongue fasiculations and sensation was normal. My other differentials would be multifocal motor neuropathy and Kennedy's disease. There were no signs of respiratory distress or bulbar involvement, which was reassuring. In order to complete my examination I would like to examine the UL and LL, findings of reduced power with a mixed upper and lower motor neuron distribution without sensory involvement, would support my impression of MND. Investigations
Less confident mixed picture
I've examined Mrs Patch's cranial nerves. There was muscle wasting and impairment of cranial nerve 5, 7 and 12 bilaterally.. The cranial nerve 5 signs were a positive jaw reflex and weak masseter muscle. Cranial nerve 7 signs were reduced movements of the face and I was able to open her eyes against resistance. Cranial nerve 12 signs showed weakness of the tongue and I noted tongue fasciculations. There was mixed UMN (the jaw jerk) and LMN (fasciculations) signs present. The differential for these would be MND, B12 subacute degeneration of the combined spinal cord- which usually would have sensory symptoms and syphillis (tabes dorsalis), which has a broad differential.
CN 1- Olfactory: sensory- smell
CN 2- Optic: Visual acuity (visual fields), pupillary sensory response
CN 3- Oculomotor: motor eyelids, pupil constriction, eye muscles- inferior oblique; medial, superior and inferior rectus
CN 4- Trochlear: motor- superior oblique
CN 5- Trigeminal: sensation of face; motor- mastication & jaw
CN 6- Abducens: motor- lateral rectus
CN 7- facial: motor movements of face V1, V2, V3, anterior 2/3rd of tongue
CN 8- Vestibulo-cochlear: hearing & balance
CN 9- Glossopharngeal: posterior 1/3rd tongue, swallowing
CN 10- Vagus: parasympathetic autonomic control of heart, lungs, mouth
CN 11- accessory: motor- head and shoulder
CN 12- hypoglossal: motor- tongue, speech
Written in 2026.