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Exam Cram
Exam Cram
Auto immune hepatitis is where the immune system attacks the liver
Presentation: 50F, 2m lethargy, jaundice, itch; deranged LFTs
Diagnosis- anti-smooth muscle antibodies
Management: steroids (good response)
Outline
Outline
Assessment
Assessment
History
Subacute tiredness, itchy
30-60yr old female
Examination
Jaundice
Scratch marks
Hepatomegaly
Investigations
Deranged LFTs: ALT > AST (both raised)
Antibodies
Anti-smooth muscle antibody
ANA
Anti- LKM
Diagnosis
Diagnosis
Diagnostic criteria: (3/3)
Exclude other causes of acute hepatitis
Clinical signs + antibodies
Liver biopsy if uncertainty
Classification:
Type 1: anti-smooth muscle antibody
Type 2: anti-LKM antibody
Management
Management
Acute
Corticosteroids
Usually a good response to steroids
Long term: maintain remission
Azathioprine (requires TPMT)
Resources and References
Resources and References
Links
Body systems: gastrointestinal, Haematopoietic & Immune systems
Specialties: Gastroenterology
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