Exam Cram

• Mixed connective tissue disease describes where multiple autoimmune diseases are simultaneously present

• Diagnosis: 

  • • Anti U1 ribonucleoprotein

    • Raynaud's

    • At least 2 connective tissue diseases: Systemic Lupus Erythematous, Systemic Sclerosis, inflammatory myositis, rheumatoid arthritis

• Management: NSAIDs, steroids and immunosuppression

Notes

• Complications include Pulmonary Hypertension (Pul HTN) and pulmonary fibrosis

• ECHO required to monitor for this at diagnosis

References and Resources

1. Sapkota B, Al Khalili Y. Mixed Connective Tissue Disease. [Updated 2024 Jul 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK542198/

Written in 2025