Tumour Lysis Syndrome

Exam Cram

• Tumour lysis syndrome is caused by massive breakdown of cells when treating leukaemia overwhelming kidney with urea

• Investigation: high urea, creatinine, phosphate and potentially hyperkalaemia 

• Management: IVF

• Prophylaxis- rasburicase

Med Reg Notes

Comparable to JH syndrome when treating spirochetes. 

Management

Acute

1. IVF

2. Rasburicase

Prophylaxis

1. Rasburicase

2. Allopurinol

Core Oncology Emergencies

• SVCO (Superior Vena Cava Obstruction) 

• HyperCalcaemia 

• Neutropenic Sepsis 

• Spinal cord compression

• Raised ICP

• Ascites or pleural effusion

• Hyper viscosity syndrome

Resources and References

Written 2024.