Primary Sclerosing Cholangitis (PSC)

Exam Cram

• Primary sclerosing cholangitis is an autoimmune attack on both intra & extrahepatic biliary ducts, with 80% of PSC pts having Ulcerative Colitis

• Presentation: tiredness, itching, xanthelasma, painless jaundice; raised alk phos & GGT

• Investigations: 1) pANCA and ANA positive, 2) MRCP

• Management: 1) USD, 2) Liver Transplant

Med Reg Notes

Biopsy: periductal concentric fibrosis- 'onion skin'

Resources and References

Written in 2025