Cryoglobulinemia

Exam Cram

• Cryo = cold

• Globulin = proteins

• Aemia = blood

• Cryoglobulinemia: proteins in blood, detected when cold

• Presentation (SKAN)

  • Skin

  • Kidneys- type mesangiocapillary glomeuronepritis

  • Arthralgia

  • Neuromas

• Investigation: cryoglobulins, low C4, raised rheumatoid factor

• Management: 

  • Plasma electrophoresis

  • Rituxumab

HCV association

Produced 2024