Serotonin Syndrome

Exam Cram

• Moa: excess serotonin, usually from medications

• Presentation: fever, rigidity, drowsiness, confusion

• Medications: SSRIs, tramadol, 

• Differentiate from NMS: hyper reflexivity and clonus

• Management:

  1. Stop offending drugs, 

  2. Benzodiazepines, 

  3. Cyproheptadine (histamine antagonist)

Written in 2024.