Multiple endocrine neoplasia (MEN)

Exam Cram

• Multiple endocrine neoplasia (MEN) is a collection of inherited syndrome associated with cancer

• MEN 1- menin gene, MEN 2- RET gene

  • Men 1a (PPP)- parathyroid, pituitary, pancreatic (commonly gastrinomas or insulinomas) cancers

  • Men 2a (TPP)- thyroid, parathyroid, phaeochromocytoma cancers

  • Men 2b (TPN)- thyroid, phaeochromocytoma, neuroma cancers

Med ReG Notes

Autosomal dominant: MEN 1, 2a & 2b

RET gene = rearranged during transfection

In children with parents who have MEN and moderate risk RET- screen for parathyroid cancer from the age of 5. 

All cases of medullary thyroid cancer are tested for MEN RET mutation. 

References

1. Rare cancers knowledgebase - multiple endocrine neoplasia syndromes (mens) (no date) Rare Cancers Australia Knowledge - Home. Available at: https://knowledge.rarecancers.org.au/knowledgebase/cancer-types/199/multiple-endocrine-neoplasia-syndromes (Accessed: 05 October 2024).

2. https://www.niddk.nih.gov/health-information/endocrine-diseases/multiple-endocrine-neoplasia-type-1#:~:text=About%2040%20percent%20of%20people,parts%20of%20the%20digestive%20tract.&text=Many%20different%20types%20of%20small,Some%20tumors%20may%20be%20cancerous. 

3. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/men2a-syndrome 

Page written in 2024.