CKD (Chronic Kidney Disease)

Exam Cram

Notes

Hypocalcaemia

In CKD impaired 1-alpha-hydroxylation of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol (active vitamin D). 

Vitamin D calcium and phosphate absorption from GI and kidney and suppress PTH's bone turnover. Therefore a reduction in vitamin D, causes lack of retention of calcium. 

Management

1. Control BP

2. Treat underlying cause

3. SGLT-2 inhibitors

Written 2024