Essential Thrombocytosis

Exam Cram

Outline

Background 

Diagnosis

Diagnostic criteria

History:

• Headaches

• Clots- TIA/ strokes

Examination:

Ix

• Platelets >> 400

• Normal haemoglobin and WCC

• JAK -2 +ve

Differentials

• Secondary thrombocytosis causes

  • • • • Malignancy

        • Chronic infection

        • Chronic bleeding, e.g. GI

        • COPD

Risk factors for thrombo-embolic disease

• Over 60 yrs

• PLT > 1500

Management

1. Hydroxyurea: aim platelets < 450

2. Interferon alpha (younger pts)

Comments

• No role of splenectomy

References

Ebstein Anomaly and Malformation - StatPearls - NCBI Bookshelf (nih.gov)