Lymphoma

Exam Cram

• Cancer of lymphocytes within lymph nodes, most common in under 60 is Hodgkin's 

• Presentation (B-symptoms): drenching night sweats, fevers, weight loss, often young individual

• Examination: painless single swollen lymph node

• Diagnosis: lymph node excision biopsy

Hodgkin's Lymphoma

Hodgkin's lymphoma presents during adolescence and is associated with a better survival than other lymphomas. 

Diagnostic criteria: lymph node excision biopsy

History

• B symptoms: night sweats, fever, weight loss

Examination

• Lymphadenopathy: painless, 'rubbery'

• Erythema nodosum

Investigation

• Normal FBC

  • Can develope bone marrow infiltration and deranged FBC

• Raised LDH

• CT: lymphadenopathy, invasive mediastinal mass

Staging

I- 

II

II

IV

A- no B symptoms; B- presence of 'B symptoms'- drenching night sweats

Management

• Haematology consult

• Consider staging CTCAP

• Chemotherapy

Complications

• Progression to Acute Myeloblastic Leukaemia 

Burkitt's Lymphoma

Aggressive form of non Hodgkin's lymphoma

Gene: C-myc

Genes (easily confused)

• BCR-ABL : CML

• BCL2:  B Cell Lymphoma (non Hodgkin's)

Mantle Cell Lymphoma

Presents with widespread lymphadenopathy, splenomegaly in later ages

Translocation- 11:14

Follicular Lymphoma

Managment

1. R-CHOP- rituxumab, cyclophosphamide, doxorubicin, vincristine, prednisolone

Diffuse Large B Cell Non Hodygkin's Lymphoma

Management

1. R-CHOP- rituxumab, cyclophosphamide, doxorubicin, vincristine, prednisolone

Resources & References

Page written 2024.