Exam Cram

• MASH (metabolic associated steato-hepatitis) describes hepatic injury in the absence of alcohol excess, presumed to be from obesity/ metabolic causes 

• Presentation: obese individual with ALT > AST transaminitis, asymptomatic

• Diagnosis: steatosis, ALT > AST & absence of cause (e.g. alcohol)

• Management: weight loss- lifestyle, liraglutide, surgery

MASH is previously called NAFLD. 

Outline

Background 

• Part of the metabolic syndrome: obesity, dyslipidaemia, hypertension, T2DM

• Common cause of liver cirrhosis & death

Assessment

History:

Examination:

Investigations

Diagnosis

Diagnostic criteria: 

Differentials: ALD

Management

1. Weight loss (see Obesity)

   • Lifestyle: exercise, diet

   • Medical: liraglutide

   • Surgical

Med Reg Notes

References

Page written in 2024.